1142 Results for: "NMR"

Supplier: Adipogen

Selective 5-HT2A serotonin receptor antagonist. ATP-sensitive potassium channel inhibitor. hERG potassium channel blocker.

Supplier: Adipogen

Potent and selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2).

Supplier: Adipogen

Nitric oxide (NO) donor. Generates both superoxide anion and nitric oxide that spontaneously form peroxynitrite. Platelet aggregation inhibitor. Guanylyl cyclase activator. Cytotoxic. Positive ionotropic. Vasodilator.

Supplier: Honeywell Research Chemicals

Chromasolv* Acetonitrile, Purity: >/-99.9% (GC), CAS Number: 75-05-8, High Purity Solvent, Molecular formula: CH3CN, Molar Weight: 41.05 g/mol, Synonym: ACN; Methyl cyanide, Container: Glass Bottle, Appearance: Colorless, Appl

Supplier: TCI America

[NMR Shift Reagent] CAS Number: 15522-71-1 MDL Number: MFCD00000019 Molecular Formula: C33H57EuO6 Molecular Weight: 701.78 Purity/Analysis Method: 95.0% (T) Form: Crystal Color: Pale Yellow Melting point (°C): 190

Supplier: Enzo Life Sciences

Apoptosis inducer.

Supplier: Chem-Impex International

N-Succinimidyl-S-acetylthioacetate is a key reagent for bioconjugation and protein labeling, enhancing drug delivery and diagnostic applications. Ideal for researchers in chemical biology and materials science.

Supplier: Chem-Impex International

4-(N-Succinimidylcarboxy)benzophenone is a key compound for bioconjugation and labeling, ideal for drug delivery systems and biomolecular probes. Its unique properties enhance imaging applications, making it essential for researchers in biochemistry and molecular biology.

Supplier: Adipogen

Neuroprotective. Mitochondrial gene expression regulator. ROS scavenger. Competitive GABA(A) receptor antagonist. Apoptosis inhibitor. CREB phosphorylation enhancer. Stimulates neurogenesis and synaptogenesis. Hepatic cytochrome P450 inducer. Activates the phosphatidylinositol 3-kinase (PI3K) dependent pathway. Potent anti-inflammatory and antihyperalgesic agent.

Supplier: Enzo Life Sciences

PI3 kinase p110beta inhibitor

Supplier: Chem-Impex International

1-N-Boc-4-bromopiperidine is a key intermediate in organic synthesis, ideal for pharmaceutical development. Its unique properties enhance stability and facilitate complex reactions, making it essential for researchers and industry professionals.

Supplier: Adipogen

Highly selective, reversible and cell permeable MEK (MAP kinase kinase) inhibitor. Blocks the phosphorylation and activation of the MAP kinase pathway. T cell activation inhibitor. Inhibits cell growth and cell proliferation of several cancer cells.

Supplier: Enzo Life Sciences

CDK/cyclin inhibitor

Supplier: Chem-Impex International

Discover the versatile applications of 4-(Trifluoromethyl)aniline, a key compound in pharmaceuticals and specialty chemicals. Enhance your research with this unique fluorinated compound, known for its improved metabolic stability and bioavailability. Ideal for drug discovery, agrochemicals, and advanced materials synthesis.

Supplier: Enzo Life Sciences

Bcl-2 ligand.

Supplier: Adipogen

Cell permeable Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Induces Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo. Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations. Potent activator of VEGF expression in vitro.

Supplier: Adipogen

Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Potential anti-cancer compound. Cell cycle arrest inducer at G1, S and G2/M·Apoptosis inducer in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards.

Supplier: Enzo Life Sciences

Prenyl flavonoid. Phytoestrogen. Selective, non-steroidal estrogen receptor α (ERα) ligand. Potent inhibitor of angiogenesis in vitro and in vivo. Chemopreventive agent against cancer induced by heterocyclic amines.

Supplier: Adipogen

Potent and selective TRPV1 antagonist. Glutamatergic synaptic transmission inhibitor.

Supplier: Adipogen

Selective JAK3 inhibitor. Blocks STAT signaling. Inducer of apoptosis via down-regulation of anti-apoptotic gene expression.

Supplier: Adipogen

Water-soluble, slow-releasing hydrogen sulfide (H2S) donor. Exhibits vasodilator and antihypertensive activity. Anti-inflammatory. Inhibits LPS-induced release of proinflammatory mediators (IL-1beta, IL-6, TNF-alpha, nitric oxide (NO) and PGE2) and increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-kappaB, ATF-2 and HSP27 dependent pathways. Causes stomatal opening and reduces nitric oxide accumulation in plants. Oxidative stress-induced cell death inhibitor. Shows novel anti-cancer effects in vitro and in vivo. Anti-thrombotic via p-selectin dependent mechanism.

Supplier: Adipogen

Potent, cell permeable, highly specific, reversible PI(3)K (phosphoinositide 3-kinase) inhibitor. pan-class I / II / III PI3K inhibitor. Acts on the ATP-binding site of the enzyme. In solution more stable than wortmannin. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Autophagy inhibitor (autophagosome formation). Inhibitor of BET bromodomain proteins BRD2, BRD3 and BRD4.

Supplier: Adipogen

Selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Inhibits superoxide generation in human neutrophils.

Supplier: Chem-Impex International

Boc-L-b-homoalanine is a key amino acid derivative used in peptide synthesis and drug development. Its unique structure enhances biological activity, making it ideal for creating novel therapeutics. Explore its applications in cyclic peptides and bioactive compounds for improved potency and selectivity.

Supplier: Adipogen

Thiazolidinedione (TZD) reference compound. Selective PPARgamma agonist. Selectively activates PPARgamma-1. Anti-diabetic , decreasing insulin resistance in adipose tissue. Is about one tenth as potent as rosiglitazone. Lipid metabolism modulator. Estrogen synthesis inhibitor. NF-kappaB inhibitor. Neuroprotective.

Supplier: Adipogen

Reactive probe containing fluorescent metal-ligand complex for determination of nucleotide base sequences.

Supplier: Adipogen

Cell permeable potent and selective cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Protein kinase Cµ (PKCµ) inhibitor. Ca2+/calmodulin-dependent protein kinase II inhibitor. Casein kinase I inhibitor. Myosin light chain kinase (MLCK) inhibitor. Apoptosis enhancer. Tool to study protein crystal structure-inhibitor interactions. Rho kinase inhibitor. Cell proliferation inhibitor. Review.

Supplier: Adipogen

Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of G1 phase cell cycle arrest. Inducer of p27Kip1. Inducer of apoptosis through the mitochondrial pathway. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway. Downregulates c-myc. Inhibitor of PRAS40 phosphorylation and mTOR activity. Potential anti-cancer compound. Blocks prostate cancer growth.

Supplier: Adipogen

A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd 7 nM). Weak and reversible inhibition of nNOS (neuronal nitric oxide synthase/NOS I) (Ki 2) and eNOS (endothelial nitric oxide synthase/NOS III) (Ki 50 µM). Inhibits tumor growth. Increases vasoconstriction to noradrenaline. Improves contractile function. Improves stroke outcome and decreases glutamate release. Anti-inflammatory. Review.

Supplier: Adipogen

Potent, water soluble poly(ADP-ribose) polymerase (PARP) inhibitor. Inhibits peroxynitrite-induced cell necrosis. Shows significant, dose-dependent anti-inflammatory effects in a variety of local inflammation models. Provides cardioprotection by decreasing myocardial infarct size. Shows protective effects in models of stroke. Suppresses cell growth in liver cancer cells.