1142 Results for: "NMR"

Supplier: Thermo Scientific Chemicals

MDL: MFCD00044639 Beilstein Registry No.: 114377

Supplier: Adipogen

Antioxidant. Free radical scavenger. Nitric oxide (NO) scavenger. Anticancer compound. Antiproliferative. Apoptosis inducer. Reduces induced DNA damage. Protective against carcinogenesis. Hypolipidaemic. Reduces triacylglycerol levels. Anti-inflammatory. Platelet aggregation inhibitor. Anti-hyperglycaemic. Anti-adipogenic. Insulin-mimetic. Activates synthesis of glucose transporter GLUT4. Neuroprotective. Cardioprotective. Reduces lipid peroxidation. Weak alpha-glucosidase inhibitor. Vasodilatory compound.

Supplier: Adipogen

Deoxymanumycin A is a derivative of the farnesyltransferase inhibitor Manumycin A.

Supplier: Adipogen

Fluorogenic substrate for esterases, broadly applied to various types of esterases, including carboxyesterases. Measurement of intracellular pH in rat proximal convoluted tubule.

Supplier: Adipogen

Cytochalasan mycotoxin, derivative of chaetoglobosin A . Phytotoxic. Cytotoxic against HCT116 (human colon cancer cells). Antibacterial (Ps. aeruginosa). Anti-inflammatory and immunomodulatory compound.

Supplier: Adipogen

Eremophilane sesquiterpene. Nontoxic secondary metabolite from Penicillium roqueforti.

Supplier: Adipogen

Fluorescent probe for detection of H2S2 and hydrogen polysulfides in aqueous buffers.

Supplier: Adipogen

Highly sensitive and selective fluorogenic H2S probe. The aromatic azide moiety of AzMC is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4-methylcoumarin (AMC) with a concomitant increase in fluorescence with lambdaex = 365 nm and lambdaem = 450 nm. Photoaffinity labeling probe for the substrate binding site of human sulfotransferase 1A1 (SULT1A1). Probe to monitor the enzymatic production of H2S in vitro and to visualize H2S in living cells. Tool for monitoring the activity of pyridoxal-5'-phosphate (PLP)-dependent enzymes (e.g. cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CGL) and tryptophan synthase (TS)). Tool to identify novel cystathionine beta-synthase (CBS) inhibitors and activators. Suitable for high-throughput screening. Caution: Use of this product with DTT, TCEP and/or biological thiols at concentrations of 25 mM should be avoided for maximum efficiency.

Supplier: Adipogen

Reference compound for the fluorescent (nitric oxide) NO probe DAR-4.

Supplier: Adipogen

Eremophilane sesquiterpenoid. Inhibitor of HIV-1 Tat transduction. Phytotoxin. Mycotoxin.

Supplier: Adipogen

Anticancer compound. Shown to inhibit progression of prostate cancer cells. Anti-obesity agent. 3T3-L1 adipocyte differentiation and FAS expression inhibitor.

Supplier: Adipogen

Potent, reversible and ATP-competitive glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) inhibitor. JAK/STAT3 signaling inhibitor. Phosphoinositide-dependent kinase 1 (PDK1) inhibitor. Anticancer compound. Potent antiproliferative agent. Suppresses metastasis. Apoptosis inducer. Sustains pluripotency and self-renewal of human and mouse embryonic stem cells (ESCs) by activation of the Wnt signaling pathway. Anti-leishmanial (IC50 = 0.150µM). Proto-oncogene tyrosine-protein kinase receptor RET inhibitor (IC50=0.51µM). Inhibits HIV-1 transcription and protects against Tat induced neurotoxicity.

Supplier: Adipogen

Cell permeable compound capable of slowing anaphase-promoting complex/cyclosome (APC/C)-dependent proteolysis. Inhibitor of the ubiquitin ligase activity of the APC/C by inhibiting substrate binding to Cdc20. Distinct mechanism of action than proTAME. Blocks mitotic exit only modestly when used alone in cultured cells. A strong synergistic effect is observed when Apcin and proTAME are used simultaneously, providing a more robust mitotic arrest. This may be very beneficial when treating cells that do not efficiently convert proTAME to its active parent compound (TAME) or if experiments demand strong APC/C inhibition.

Supplier: Adipogen

Building block for oligonucleotide synthesis.

Supplier: Adipogen

Reference compound for the fluorescent (nitric oxide) NO probe DAR-4M.

Supplier: Adipogen

Adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 less potent than AdipoRon http://www.adipogen.com/ag-cr1-0154/adiporon.html . Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms.

Supplier: Adipogen

Isomeric to pseurotin A . Anticancer and antiparasitic compound. Apomorphine antagonist. Neuroleptic agent. Inhibitor of IgE production.

Supplier: Adipogen

Cytochalasan mycotoxin, derivative of chaetoglobosin A . Phytotoxic and antifungal compound. Moderate cytotoxic compound.

Supplier: Adipogen

HPLC-precolumn-derivatization reagent for carboxylic acids. Compared to classical BMC it emits at longer wavelength and has stronger fluorescence.

Supplier: Adipogen

Indole alkaloid. Monoamine oxidase inhibitor (MAOI). Antiepileptic (anticonvulsant) compound. Inhibitor of platelet aggregation and thromboxane A2 synthesis. Weak antifungal and antituberculosis activity. Useful as lead structure for potent antifungal substances.

Supplier: Adipogen

Cell permeable, non-alkylating, non-thiol, adduct-forming, redox cycling quinone. Intracellular superoxide anion formation/ROS generation inducer. Anticancer agent. Shown to induce cell proliferation, apoptosis, necrosis and necroptosis in vitro, dependent on concentration, time, temperature and cell type. Valuable tool for the generation of reactive oxygen species (ROS) in order to study the role of ROS in cell toxicity, apoptosis and necrosis. Useful as reference compound in characterizing the effects of oxidative stress. Can be used to eliminate any mechanistic ambiguity involving redox cycling quinoids as the source of reactive oxidant species/oxidative stress in biological studies.

Supplier: Adipogen

Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane permeable Smoothened (Smo) antagonist. Acts on extra- and intracellular exposed Smo. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.

Supplier: Adipogen

Nitrophenyl pyranone derivative related to aureothin . Insecticidal and nematocidal compound. Metabolites within this product class show pronounced antitumor and immunosuppressive activity.

Supplier: Adipogen

Reference compound for the fluorescent (nitric oxide) NO probe DAR-M.

Supplier: Chem-Impex International

Boc-(±)-trans-4-(4-chlorophenyl)pyrrolidine-3-carboxylic acid ≥98% (NMR)

Supplier: Chem-Impex International

1-Isopropyl-2,5-dimethyl-1H-pyrrole-3-carbaldehyde ≥95% (NMR)

Supplier: Adipogen

Cell permeable, potent and selective cyclin-dependent kinase CDK-1 (CDC2), -2 and -5 inhibitor. Apoptosis inducer. Antitumor agent. Inhibits cell cycle progression at the G1/S and G2/M transitions. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Important probe for understanding the cellular roles of CDKs. Inhibitor of alpha-glucosidases. Maturation inhibitor of sheep oocytes.

Supplier: Adipogen

Some cationic mitochondrial dyes such as 4-Di-1-ASP and 4-Di-2-ASP stain presynaptic nerve terminals independent of neuronal activity. The photostable 4-Di-2-ASP dye, which is nontoxic to cells, has been employed to stain living nerve terminals in rabbit corneal epithelium, in rat epidermis and at mouse, snake and frog neuromuscular junctions, as well as to visualize the innervation of the human choroid and whole mounts of the gastrointestinal tract. Methods for using 4-Di-2-ASP to image neuronal cells in live animals have been described (Ex/Em = 488/607 nm).

Supplier: Adipogen

Sterigmatocystin is an intermediate of the biosynthetic pathway to Aflatoxin B1.

Supplier: Adipogen

Specific histidine decarboxylase inhibitor. Anti-inflammatory. COX-1 inhibitor. Antioxidant flavonoid. Free radical scavenger. Inhibits lipid peroxidation. Antimetastatic and anticancer compound. Antiangiogenic. Anti-osteoporotic. Antibacterial and antifungal. Neuroprotective. Mono oxidase B inhibitor. Apoptosis and cell cycle arrest inducer. JNK phosphorylation inhibitor. Antispasmodic. Insulin-mimetic.