1142 Results for: "NMR"

Supplier: Adipogen

Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5 and CDK9. Apoptosis inducer. Inhibits the proliferation of various cancer cell lines. Casein kinase 1 (CK1delta/epsilon) inhibitor. Potential anti-inflammatory compound. Potential antidiabetic compound.

Supplier: Adipogen

Selective Ub-conjugating enzyme (E2) complex Ubc13-Uev1A inhibitor. Inhibits the formation of the Ubc13~Ub conjugate. NF-kappaB activation inhibitor. Inhibits proliferation and survival of ABC-DLBCL and GCB-DLBCL (diffuse large B cell lymphoma) cells.

Supplier: Thermo Scientific Chemicals

Packaged in 1 ml ampoules

Supplier: Adipogen

Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.

Supplier: Thermo Scientific Chemicals

Deuterium chloride 20% (w/w) in D₂O 99+ atom % D for NMR spectroscopy

Supplier: Ace Glass

Use to tip-off NMR tubes

Supplier: Adipogen

Cell-permeable fluorescent probe for sensitive (detection limit ~71 nM) and selective detection of H2S2 and hydrogen polysulfides in aqueous buffers as well as in cells/biological systems. Shows almost no cytotoxicity and can be used in detecting H2Sn (not H2S) in cells.

Supplier: Adipogen

Polarity fluorescent probe.

Supplier: Thermo Scientific Chemicals

Methanol-[D₄] (99.8% D) + 0.03% (v/v) TMS, AcroSeal™ for NMR spectroscopy

Supplier: Adipogen

Reagent used as a catalyst for cross-coupling reactions between alkyl halides and carbon nucleophiles. Catalyst for alkyl-alkyl Kumada coupling of secondary alkyl halides, direct alkylation of heterocyclic C-H bonds, Sonogashira coupling of nonactivated alkyl halides, Kumada-Corriu-Tamao coupling of nonactivated alkyl halides with aryl and heteroaryl nucleophiles. Reactant of pincer NN2 ligand leading to selective carbon-carbon bond formation.

Supplier: Adipogen

N-methylated inactive control analog of 6-bromoindirubin-3'-oxime (6BIO) . Displays minimal activity against CDK1/Cyclin B, GSK-3 alpha/beta and CDK5/p25. Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.

Supplier: Adipogen

Hydrogen sulfide (H2S) is an important gaseous mediator, like nitric oxide, that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. WSP-1 is a reactive disulfide-containing, fluorescent probe designed to detect H2S in biological samples and cells. Through a reaction-based fluorescent turn-on strategy, WSP-1 selectively and rapidly reacts with H2S to generate benzodithiolone and a fluorophore with excitation and emission maxima of 465 and 515 nm, respectively.

Supplier: Adipogen

Labeling of cell-surface functional groups (glycophorins). Detection of protein carbonyls in aging tissues.

Supplier: Chem-Impex International

5-(3-Hydroxyprop-1-yn-1-yl)thiophene-2-carbaldehyde ≥95% (NMR)

Supplier: Chem-Impex International

2,7-Dimethyl-1H-indole-3-carbaldehyde ≥95% (NMR)

Supplier: Thermo Scientific Chemicals

Deuterium oxide 99.8 atom % D, AcroSeal™ for NMR spectroscopy

Supplier: Chem-Impex International

5-Fluoro-2-(1H-pyrazol-1-yl)benzaldehyde ≥95% (NMR)

Supplier: Ambeed

Polyethylene glycol mono-4-nonylphenyl ether ≥98% (by NMR)

Supplier: Adipogen

Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low µm concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice.

Supplier: Adipogen

Photo-stable fluorescent probe for the detection of nitric oxide (NO).

Supplier: Thermo Scientific Chemicals

MDL: MFCD00000827

Supplier: Adipogen

Highly potent, selective and reversible cell permeable inhibitor of the proteasome. Inhibits the chymotrypsin-like and caspase-like peptidase activity of the proteasome. Calpain and cathepsin inhibitor. Autophagy activator. Anticancer compound. Inhibits proliferation and migration of several tumor cell lines with nanomolar potency. Apoptosis inducer.

Supplier: Thermo Scientific Chemicals

MDL: MFCD00044239

Supplier: Thermo Scientific Chemicals

MDL: MFCD00044637

Supplier: Adipogen

Specific histone acetyltransferase Gcn5 inhibitor. Anticancer compound. Pre-mRNA splicing inhibitor. Blocks splicing before the first catalytic steps. Potential anti-inflammatory compound.

Supplier: Thermo Scientific Chemicals

MDL: MFCD00044635 Notes: Minimum isotopic purity 99.96%

Supplier: Adipogen

Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory. Anti-gastric ulcer. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor.

Supplier: Chem-Impex International

4-[(2-Methyl-2-propen-1-yl)oxy]benzaldehyde ≥95% (NMR)

Supplier: Chem-Impex International

2,4,5-Trimethyl-1H-pyrrole-3-carbaldehyde ≥95% (NMR)

Supplier: Chem-Impex International

(2,6-Dimethoxy-4-methylphenyl)boronic acid ≥95% (NMR)