1142 Results for: "NMR"

Supplier: Chem-Impex International

Nb-Boc-Nw-Z-L-b-homolysine ≥97% (NMR)

Supplier: Thermo Scientific Chemicals

MDL: MFCD00000882

Supplier: Adipogen

Aurora A and B modulator.

Supplier: Adipogen

Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds).

Supplier: Thermo Scientific Chemicals

MDL: MFCD00044341

Supplier: Thermo Scientific Chemicals

MDL: MFCD00044563

Supplier: Adipogen

Nucleoside antibiotic (amicetin group)

Supplier: Thermo Scientific Chemicals

Acetic acid-[D₄] 99.5 atom % D for NMR spectroscopy

Supplier: Thermo Scientific Chemicals

Dimethyl sulfoxide-[D₆] 99.9 atom % D for NMR spectroscopy

Supplier: Thermo Scientific Chemicals

MDL: MFCD00002090

Supplier: Adipogen

Used as an excipient (an inert substance) in pharmaceuticals that improves solubility, drug release rate and stabilization of anionic drug substances. Counter ion used to replace sodium. It is impermeable towards cell membranes with comparable osmotic activity like sodium. Widely used in the preparation of contrast/radiopaque media in combination with iodine containing compounds, such as diatrizoate meglumine and iodipamide meglumine. Examples of meglumine-combined drugs are flunixin meglumine (used as a veterinary anti-inflammatory and analgesic) and meglumine antimoniate (antiprotozoal to treat leishmaniasis).

Supplier: Adipogen

Control for H2S2 and hydrogen polysulfides probes.

Supplier: Adipogen

Suitable for amino acid or protein sequence analysis by HPLC with fluorescence detection.

Supplier: Adipogen

Antimitotic alkaloid. Tubulin polymerization and microtubule assembly inhibitor. Axonal cytoskeleton modulator. Inhibitor of autophagosome-lysosome fusion. Apoptosis inducer. Thiocolchicine-dimers were shown to be potent topoisomerase I inhibitors.

Supplier: Adipogen

Antibiotic

Supplier: Adipogen

Anticancer compound. Caspase-independent, non-apoptotic cell death inducer. ATP-competitive Flt3 inhibitor. Necrosis inducer. Aurora B and C kinase inhibitor. DYRK1A and DYRK 2 (Dual-specificity tyrosine phosphorylation-regulated kinase) inhibitor. Inflammasome activator.

Supplier: Adipogen

Modified base of mammalian DNA. Involved in regulation of stem cell processes, cellular development, neurodegeneration and carcinogenesis. Important epigenetic marker. Related to bacimethrin .

Supplier: Thermo Scientific Chemicals

MDL: MFCD00037106

Supplier: Adipogen

Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5, CDK7 and CDK9. Pyridoxal kinase (PDXK) inhibitor. Triggers cell apoptotic cell death. Down-regulates Mcl-1 and MYCN. Anticancer compound. Kills chronic lymphocytic leukemia (LLC) cells and slows tumor growth in mouse xenografts. Inhibits cysts formation in culture and in polycystic kidney disease (PKD) mouse models. Potential anti-inflammatory compound that can influence the resolution of inflammation. Potential antidiabetic compound. Shown to protect pancreatic beta-cells from glucotoxicity and increase insulin secretion. Shows antiviral properties. Neuroprotective in brain trauma. Has positive effects on Timothy syndrome cells. Used for cloning of mammals by synchronization of nucleus donor cells. Provides neuroprotection in experimental traumatic brain injury.

Supplier: Adipogen

Excellent blue fluorescent thiol-reactive reagent (Ex/Em: 383/463nm), widely used for probing configurations of biomolecules such as proteins and create blue-fluorescent bioconjugates. The unreacted reagent is non-fluorescent and can also be used to quantitate free thiols. Shows superior fluorescence and water solubility properties than dansyl chloride.

Supplier: Adipogen

Toxic sesquiterpenoid. Exhibits expectorant and antitussive effect. Reported to increase blood pressure. Antifungal compound.

Supplier: Adipogen

Shows calcium-antagonistic and vasorelaxant activity. Antibacterial. Anti-inflammatory. Potent COX-2 and inducible nitric oxide (iNOS; NOS II) inhibitor. Hepatoprotective. Anticancer compound. Apoptosis inducer. Neuroprotective antioxidant. Antifungal.

Supplier: Adipogen

Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5, CDK7 and CDK9. Apoptosis inducer. Inhibits the proliferation of various cancer cell lines. Casein kinase 1 (CK1delta/epsilon) and glycogen synthase kinase (GSK-3alpha/beta) inhibitor. Potential anti-inflammatory compound. Potential antidiabetic compound.

Supplier: TCI America

[for NMR] CAS Number: 75-76-3 MDL Number: MFCD00008274 Molecular Formula: C4H12Si Molecular Weight: 88.23 Purity/Analysis Method: 99.0% (GC) Form: Clear Liquid Color: Colorless Boiling point (°C): 26 Flash Point (°C): -27 Specific Gravity (20/20): 0.64 Storage Temperature: 0-10°C

Supplier: Thermo Scientific Chemicals

MDL: MFCD00002090 Notes: Minimum isotopic purity 99.96%

Supplier: Adipogen

Photo-stable fluorescent probe (Ex: ~565nm; Em: 580nm) for the detection of nitric oxide (NO).

Supplier: Adipogen

Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.

Supplier: Adipogen

N-methylated inactive control compound for 7BIO . Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.

Supplier: Adipogen

Cell-permeable fluorescent probe for sensitive (detection limit ~71 nM) and selective detection of H2S2 and hydrogen polysulfides in aqueous buffers as well as in cells/biological systems. Shows almost no cytotoxicity and can be used in detecting H2Sn (not H2S) in cells.

Supplier: Adipogen

Selective Ub-conjugating enzyme (E2) complex Ubc13-Uev1A inhibitor. Inhibits the formation of the Ubc13~Ub conjugate. NF-kappaB activation inhibitor. Inhibits proliferation and survival of ABC-DLBCL and GCB-DLBCL (diffuse large B cell lymphoma) cells.