You searched for: Antibodies

Supplier: Rockland Immunochemical

Suitable for immunoblotting, ELISA, immunochemistry, immunomicroscopy as well as other antibody based assays using streptavidin or avidin conjugates requiring extremely low background levels, absence of F(c) mediated binding, lot-to-lot consistency, high titer specificity.

Supplier: Rockland Immunochemical

This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band at ~ 168 kDa corresponding to full length Protein as well as multiple bands.

Supplier: Rockland Immunochemical

Anti-Mouse Igg (Handl) (Goat) Antibody (Min X Rat Serum Proteins) - 610-101-032 Mouse Igg (Handl) Antibody Pre-Adsorbed 10 Mg

Supplier: Rockland Immunochemical

Rockland produces highly active antibodies and conjugates to collagens. Collagens are highly conserved throughout evolution and are characterized by an uninterrupted ''Glycine-X-Y'' triplet repeat that is a necessary part of the triple helical structure. For these reasons, it is often extremely difficult to generate antibodies with specificities to collagens. The development of ‘type’ specific antibodies is dependent on NON-DENATURED three-dimensional epitopes. Rockland extensively purifies collagens for immunization from human and bovine placenta and cartilage by limited pepsin digestion and selective salt precipitation. This preparation results in a native conformation of the protein. Antibodies are isolated from rabbit antiserum and are extensively cross-adsorbed by immunoaffinity purification to produce 'type' specific antibodies. Greatly diminished reactivity and selectivity of these antibodies will result if denaturing and reducing conditions are used for SDS-PAGE and immunoblotting.

Supplier: Rockland Immunochemical

Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by one of two beta-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer's disease patient's brains. Recently, Death Receptor 6 (DR6) was found to interact with an amino-terminal fragment of the beta-amyloid protein (N-APP) in neurons, activating a caspase 6-dependent apoptotic event leading to axonal degeneration and pruning during development, suggesting that these two proteins are involved in neural development and may possibly play a role in Alzheimer's disease.

Supplier: Rockland Immunochemical

Gata1, also know as erythoid transcription factor, is critical in red blood cell and platelet structure and development. It regulates the switch from fetal hemoglobulin to adult hemoglobulin. Anti-Gata1 antibody is ideal for researchers interested in cell growth and cancer research.

Supplier: Tonbo Biosciences

Goat anti-mouse IgG (H+L), secondary antibody, SureLight® R-Phycoerythrin, 100ug

Supplier: Rockland Immunochemical

The complement regulatory protein CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis and is involved in lymphocyte signal transduction. CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and ultimately cerebral infarction.

Supplier: Rockland Immunochemical

Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Supplier: Rockland Immunochemical

IgG (H&L), Polyclonal Antibody, Host: Goat, Target Species: Armenian Hamster, Format: IgG, Immunogen: Armenian Hamster IgG whole molecule, Synonyms: hamster secondary antibody, Anti-Hamster IgG, Applications: ELISA, Western Blot, Immunohistochemistry, Size: 50mg

Supplier: Rockland Immunochemical

Anti-Bilirubin Oxidase antibody is an enzyme that increases the oxidation rate of bilirubin to biliverdin and other substrates. It is ideal for investigators interested in Metabolism or Signal Transduction research.

Supplier: Rockland Immunochemical

Anti-Goat Igg (Handl) (Chicken) Antibody Peroxidase Conjugated - 605-9302 Goat Igg (Handl) Antibody Peroxidase Conjugated 1 Mg

Supplier: Rockland Immunochemical

Beta Amyloid functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. It is expressed in all fetal tissues with the highest levels located in the brain, kidney, heart and spleen tissue. It is involved in cell mobility, transcription regulation via protein-protein interactions and copper homeostasis/oxidative stress through copper ion reduction. The copper-metallated APP induces neuronal death directly in vitro, or is potentiated through Cu2+ mediated low-density lipoprotein oxidation. It has binding capabilities via its C-terminus for transient metals such as copper, zinc and iron. It binds APBB1-KAT5 to promote transcription activation and inhibits Notch signaling through interaction with Numb. It also promotes tau aggregation and TPK II-mediated phosphorylation. Anti-Beta Amyloid regulates neurite outgrowth by binding components in the cellular matrix such as heparin, collagen I and amyloid-beta peptide, leading to mitochondrial dysfunction in cultured cortical neurons. Defects in APP cause Alzheimer disease type 1 and cerebral amyloid angiopathy. This antibody is ideal for researchers interested in Cancer or Neuroscience research.

Supplier: Rockland Immunochemical

F(ab')2 Guinea Pig IgG F(ab')2, Polyclonal antibody, Host: Rabbit, Store vial at 4degree C prior to restoration, Application: Suitable for immunomicroscopy and flow cytometry or FACS analysis as well as other antibody based fluorescent assays, 20mg

Supplier: Rockland Immunochemical

This purified antibody has been tested for use in ELISA and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band at ~37 kDa in size corresponding to SAE1 Protein by western blotting in the appropriate cell lysate.

Supplier: Rockland Immunochemical

This affinity-purified antibody was tested for use in western blotting against RFA2 containing cell lysates and by ELISA against the immunizing peptide.  Reactivity in other immunoassays is unknown.

Supplier: Rockland Immunochemical

This affinity purified antibody has been tested as suitable for immunofluorescence microscopy. Antibody may be suitable for additional immunoassays including western blot, flow cytometry and immunochemistry.

Supplier: Rockland Immunochemical

F(ab')2 Golden Syrian Hamster IgG (HandL), Polyclonal antibody, Host: Rabbit, Store vial at 4degree C prior to restoration, Application: Elisa, WB, Ihc, Suitable for immunomicroscopy and flow cytometry or FACS analysis as well as other antibody based fluorescent assays, 20mg

Supplier: Rockland Immunochemical

AKT is a component of the PI-3 kinase pathway and is activated by phosphorylation at Ser 473 and Thr 308. AKT is a cytoplasmic protein also known as AKT1, Protein Kinase B (PKB) and rac (related to A and C kinases). AKT is a key regulator of many signal transduction pathways. AKT Exhibits tight control over cell proliferation and cell viability. Overexpression or inappropriate activation of AKT is noted in many types of cancer. AKT mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. AKT has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation. Anti-AKT Antibody is ideal for investigators involved in Cell Signaling, Cancer, Neuroscience, Signal Transduction research.

Supplier: Rockland Immunochemical

Goat Anti-Red Fluorecent Protein Antibody

Supplier: Rockland Immunochemical

Anti-Goat Igg (Handl) (Mouse) Antibody Texas Red Conjugated - 605-309-002 Goat Igg (Handl) Antibody Texas Red Conjugated 1 Mg

Supplier: TCI America

Purified mouse monoclonal antibody/IgM, κ-chain

Supplier: Rockland Immunochemical

Anti-PhosphoTyrosine antibody is suitable for use in ELISA and western blotting assays.

Supplier: Rockland Immunochemical

Anti-Glucose Oxidase (Goat) Antibody - 200-101-037 Glucose Oxidase Antibody 100Ug

Supplier: Rockland Immunochemical

F(ab')2 Horse IgG (HandL), Polyclonal antibody, Host: Rabbit, Store vial at 4degree C prior to restoration, Concentration: 10.0 mg/mL by UV absorbance at 280 nm, Application: Elisa, WB, Ihc, 20mg

Supplier: Rockland Immunochemical

This purified antibody has been tested for use in neutralizations, ELISA and western blotting. Reactivity is also expected in radioimmunoassay.

Supplier: Rockland Immunochemical

This purified antibody has been tested for use in neutralizations, ELISA and western blotting. Reactivity is also expected in radioimmunoassay.

Supplier: Rockland Immunochemical

F(ab')2 Guinea Pig IgG F(ab')2, Polyclonal antibody, Host: Rabbit, Label: Hrp, Store vial at 4degree C prior to restoration, Application: Suitable for immunomicroscopy and flow cytometry or FACS analysis as well as other antibody based fluorescent assays, 20mg

Supplier: Rockland Immunochemical

This affinity purified antibody has been tested for use in immunofluorescence staining of cultured cells and western blotting using transfected cell lysates.  The antibody is also functional by ELISA.  Reactivity in other immunoassays is unknown.

Supplier: Rockland Immunochemical

Anti-Bg37 Tgr5 Antibody Detects Human Bg37Tgr5. Bg37 Is A 330 Amino Acid Novel Enzyme With Seven Transmembrane Domains. It Belongs To The G Protein-Coupled Receptor (Gpcr) Superfamily And Functions As A Cell Surface Receptor For Bile Acids.